A dipole-moment study of substituted pyrazines and quinoxalines |
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Authors: | H. Lumbroso J. Curé T. Konakahara Y. Takagi |
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Affiliation: | Laboratoire de Chimie Générale, Université Pierre et Marie Curie, 4 place Jussieu, 75230 Paris Cedex 05 France;Department of Applied Chemistry, Science University of Tokyo, Kagurazaka, Shinjuku-ku, Tokyo 162 Japan |
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Abstract: | An attempt has been made to rationalize the dipole moments of 2-chloro-, 2-ethoxy-, 2-ethylthio-, 2-amino-, 2-ethylamino- and 2-diethylamino-pyrazine in terms of substituentring mesomeric effect. In 2-substituted pyrazines, the substituent mainly interacts with the ortho-to-substituent ring-nitrogen atom. Preferred conformations are proposed for 2-ethoxypyrazine and 2-methoxypyridine, 2-ethylthiopyrazine and 2-methylthiopyridine, 2,5-diethoxypyrazine, 2,3-dimethoxyquinoxaline and 2,3-bis(methylthio)quinoxaline. The dipole moments of aminopyridines, amino-s-triazine and methoxy-s-triazine are also interpreted. |
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