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DNA cleavage reaction of antitumour antibiotic, kapurimycin A3, with deoxytetranucleotide d(CGCG)2 |
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| Authors: | Kit Lam Chan Hiroshi Sugiyama and Isao Saito Mitsunobu Hara |
| Institution: | Department of Synthetic Chemistry, Faculty of Engineering, Kyoto University, Kyoto 606, Japan Tokyo Research Laboratories, Kyowa Hakko Kogyo, Co., Ltd., Mahica, Tokyo 194, Japan |
| Abstract: | Kapurimycin A3 (kap A3, 1 ), an antitumour antibiotic, alkylates N7 of guanine2 (G2) and G4 of d(C1G2C3G4)2 to produce their covalent adducts 2 (64 %) and 3 (7.0 %), respectively. Heating at 90 °C for 5 min degraded both adducts to kap A3 - G adduct (5) with the concurrent release of their respective abasic-site containing oligomers 4 and 6. |
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