| 含萘磺酰基N_3O_2大环化合物与DNA相互作用的光谱法研究 |
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| 引用本文： | 陈稼轩,田怡,向清祥,张丽群,熊俊如. 含萘磺酰基N_3O_2大环化合物与DNA相互作用的光谱法研究[J]. 有机化学, 2010, 30(1): 66-71 |
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| 作者姓名： | 陈稼轩 田怡 向清祥 张丽群 熊俊如 |
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| 作者单位： | 乐山师范学院化学与生命科学学院,乐山,614004 |
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| 基金项目： | 四川高校重点实验室专项（NO. 2006ZD049）;四川省教育厅（NO. 07ZC023）;乐山师范学院（NO. Z07045）项目 |
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| 摘 要： | 以8,1 1,14-三氮杂-5,6:16,17-二苯并-1,4-二氧杂环十七烷为原料,合成了含萘磺酰基的N_3O_2大环化合物,其结构经~1H NMR,MS,元素分析等表征.通过紫外光谱法和荧光光谱法研究了N_3O_2大环化合物与小牛胸腺DNA的作用机制.结果表明:N_3O_2大环化合物通过嵌插方式与DNA结合,结合常数为K_(298.2 K)~■=20706.9 dm~3·mol~(-1),K_(308.2 K)~■=12416.9 dm~3·mol~(-1),二者结合为焓驱动反应.
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| 关 键 词： | N3O2大环化合物 合成 小牛胸腺DNA 光谱 |
| 收稿时间： | 2009-03-25 |
| 修稿时间： | 2009-06-25 |
Spectroscopy Studies of Interactions between DNA and N_3O_2-Donor Macrocycle Bearing Naphathalic Sulfonic Group |
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| Chen Jiaxuan,Tian Yi,Xiang Qingxiang,Zhang Liqun,Xiong Junru. Spectroscopy Studies of Interactions between DNA and N_3O_2-Donor Macrocycle Bearing Naphathalic Sulfonic Group[J]. Chinese Journal of Organic Chemistry, 2010, 30(1): 66-71 |
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| Authors: | Chen Jiaxuan Tian Yi Xiang Qingxiang Zhang Liqun Xiong Junru |
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| Affiliation: | (Department of Chemistry and Life Science，Leshan Teachers College，Leshan 614004) |
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| Abstract: | A N_3O_2-donor macrocycle beating a naphathalic suifonic group derived from 8,11,14-triaza-5,6:16,17-dibenzo-1,4-dioxacycloheptadecane has been synthesized,and its structure was characterized by ~1H NMR,MS data and elemental analysis.The interactions of the target compound with CT(calf thymus)DNA have been investigated by the ultraviolet spectrophotometry and fluorescence spectrophotometry.The results showed that the binding model between the N_3O_2-donor macrocycle and CT DNA was intercalation,with the binding constants being K_(298.2K)~(θ)=20706.9dm~3·mol~(-1) and K_(308.2K)~(θ).The combination was the enthalpy driven reaction. |
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| Keywords: | N3O2-donor macrocycle synthesis CT DNA spectrum |
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