Electrocatalytic detection of thiols using an edge plane pyrolytic graphite electrode |
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Authors: | Moore Ryan R Banks Craig E Compton Richard G |
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Institution: | Physical and Theoretical Chemistry Laboratory, Oxford University, South Parks Road, Oxford, UKOX1 3QZ. |
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Abstract: | The first example of using an edge plane pyrolytic graphite electrode in electroanalysis is reported as the determination of homocysteine, N-acetylcysteine, cysteine and glutathione is studied. The response of the electrode in the direct oxidation of thiol moieties is explored and found to be electrocatalytic producing a reduction in the overpotential while having enhanced signal-to-noise characteristics compared to glassy carbon and basal plane pyrolytic graphite electrodes. The effectiveness of the methodology is examined in the determination of cysteine species in a growth tissue media that contains a high number of common biological interferences. The advantageous properties of this electrode for thiol determination lie in its excellent catalytic activity, sensitivity and simplicity. |
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