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A novel small molecule fluorescent sensor for Zn2+ based on pyridine-pyridone scaffold |
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| Authors: | Hagimori Masayori Mizuyama Naoko Yamaguchi Yasuchika Saji Hideo Tominaga Yoshinori |
| Institution: | a Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo 859-3298, Japan b Department of Hospital Pharmacy, Saga University Hospital, 5-1-1 Nabeshima, Saga 849-8521, Japan c Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan d Faculty of Environmental Studies, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan |
| Abstract: | The development of a water-soluble and small molecular weight fluorescent probe, 3-(4-methoxyphenyl)-4-(methylsulfanyl)-6-(pyridin-2-yl)pyridin-2(1H)-one (3), for detecting Zn2+ based on pyridine-pyridone skeleton is reported. We observed a clear chelation enhanced fluorescence effect of 3 in the presence of Zn2+. Other fluorescent properties of 3 are discussed. |
| Keywords: | Zn2+ Fluorescent sensor Pyridine-pyridone Small molecule Water-soluble |
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