Synthetic transformations of sesquiterpene lactones. V.* Synthesis and cytotoxicity of 13-aryl-substituted tourneforin derivatives |
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| Authors: | E E Shulˈts S S Patrushev A V Belovodskii M M Shakirov T V Rybalova A G Pokrovskii M A Pokrovskii G A Tolstikov S M Adekenov |
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| Institution: | (1) N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, Russia;(2) Novosibirsk State University, Novosibirsk, Russia;(3) International Scientific-Production Holding Fitokhimiya, 100009 Karaganda, Republic of Kazakhstan |
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| Abstract: | 13-Aryl-substituted tourneforin derivatives were synthesized via the Heck reaction with aryliodides. The structure of (E)-13-(3,4-dimethoxybenzyl)-eudesma-4(5),11(13)-dien-6α,12-olide was confirmed by an XSA. A study of the cytotoxicity of the synthesized derivatives for CEM-13, MT-4, and U-937
tumor models showed promise for the modification. |
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