Synthesis of new chiral fluorescent sensors and their applications in enantioselective discrimination |
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| Authors: | Xueyan Zhang Qiuhan Yu Weiweng Lu Shengxin Chen Zhenya Dai |
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| Institution: | Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, PR China |
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| Abstract: | New chiral fluorescent sensors derived from tetraphenylethylene and proline hydrazide were synthesized and applied in the chiral recognition of various chiral compounds, including unprotected amino acids, acidic compounds, chiral amines and even neutral alcohols. These results demonstrated that the excellent enantioselective response ability to various chiral substrates could be attributed to the –NH moieties of pyrrolidine ring and thiourea unit which acted as hydrogen-bonding donors. This result is of potential significance in enantiomeric discrimination and high-throughput analysis of the enantiomeric purity of chiral guests. |
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| Keywords: | Aggregation-induced emission Proline hydrazide thiourea Chiral recognition Chiral fluorescent sensor |
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