Cytotoxic gephyromycins from the Streptomyces sp. SS13I |
| |
| Authors: | Yong-Jun Jiang Li-She Gan Wan-Jing Ding Zhe Chen Zhong-Jun Ma |
| |
| Affiliation: | 1. Institute of Marine Biology, Ocean College, Zhejiang University, Zhoushan 316021, People’s Republic of China;2. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People’s Republic of China;3. Zhejiang Key Laboratory of Gastro-Intestinal Pathophysiology, Zhejiang Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, Hangzhou 310006, People’s Republic of China |
| |
| Abstract: | Two new gephyromycins (1–2), belonging to angucyclinones, were identified from Streptomyces sp. SS13I. Their structures were elucidated by analysis of HRESIMS, 1D and 2D NMR spectroscopic data, and the structure of 1 was further elucidated by X-ray diffraction data. The absolute configurations of compounds 1–2 were evidenced by ECD calculations. To our best knowledge, Compounds 1–2 were the second reported gephyromycin-type angucyclinones. Compound 2 exhibited significant cytotoxicity against PC3 cell lines with IC50 values of 1.38 ± 0.47 μM. |
| |
| Keywords: | Angucyclinones Gephyromycins X-ray diffraction ECD calculations Cytotoxicity |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
