Pd(II)-catalyzed enantioselective intramolecular oxidative amination utilizing (+)-camphorsulfonic acid |
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| Authors: | Andrew H. Aebly Trevor J. Rainey |
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| Affiliation: | Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA |
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| Abstract: | An enantioselective Pd(II)-catalyzed intramolecular oxidative amination reaction was developed utilizing the commercially available chiral X-type ligand (1S)-(+)-camphorsulfonic acid. The Wacker-type cyclization produced chiral indoline products with enantioselectivies up to 45% ee. Electronic structure calculations employing density functional theory support a trans-aminopalladation mechanism. |
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| Keywords: | Oxidative amination Pd(II) catalysis Chiral sulfonic acid Indolines |
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