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A three-component one-pot synthesis of penta-substituted pyrroles via ring opening of α-nitroepoxides |
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| Authors: | Donghong Zhao Yue Zhu Shanshan Guo Wenteng Chen Guolin Zhang Yongping Yu |
| Institution: | Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China |
| Abstract: | A novel and facile one-pot reaction has been developed to synthesize a variety of penta-substituted pyrroles from α-nitroepoxides, primary amines and dialkyl acetylenedicarboxylates under the conditions without catalyst. Furthermore, the controlled experiments has been performed and a possible mechanism has also been proposed. |
| Keywords: | Penta-substituted pyrroles α-nitroepoxides Primary amines Dialkyl acetylenedicarboxylates One-pot synthesis |
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