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Amphimedonoic acid and psammaplysene E,novel brominated alkaloids from Amphimedon sp. |
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| Authors: | Pierre-Eric Campos Jean-Luc Wolfender Emerson F Queiroz Laurence Marcourt Ali Al-Mourabit Nicole De Voogd Bertrand Illien Anne Gauvin-Bialecki |
| Institution: | 1. Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments, Faculté des Sciences et Technologies, Université de La Réunion, 15 Avenue René Cassin, CS 92003, 97744 Saint-Denis Cedex 9, La Réunion, France;2. School of Pharmaceutical Sciences, EPGL, University of Geneva, University of Lausanne, Quai Ernest-Ansermet 30, CH-1211 Geneva 4, Switzerland;3. Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Univ. Paris-Sud, Université Paris-Saclay, 1, av. de la Terrasse, 91198 Gif-sur-Yvette, France;4. Naturalis Biodiversity Center, Darwinweg 2, 2333 CR Leiden, Netherlands |
| Abstract: | Examination of the CH2Cl2-MeOH (1:1) extract from the Madagascan sponge Amphimedon sp. highlighted two new brominated alkaloids, amphimedonoic acid (1) and psammaplysene E (2), along with the known 3,5-dibromo-4-methoxybenzoic acid (3). Their structures were elucidated by 1D and 2D NMR spectroscopy and HRESIMS data. |
| Keywords: | Amphimedon Alkaloids Marine sponge Bromotyrosine derivated |
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