Copper-catalyzed synthesis of 2-sulfenylindoles from indoline-2-thiones and aryl iodides |
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| Authors: | Shiping Zhou Genhua Xiao Yun Liang |
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| Institution: | Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education, Key Laboratory of the Assembly and Application of Organic Functional Molecules, Hunan Normal University, Changsha, Hunan 410081, China |
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| Abstract: | A novel and efficient method for synthesis of 2-sulfenylindole via copper-catalyzed coupling reaction of indoline-2-thiones with aryl iodides has been developed. A series of N-substituted and N-free 2-sulfenylindole were obtained in high yields. Furthermore, the method was employed to synthesis of benzothieno2,3-b]indoles from indoline-2-thiones with 1,2-diiodobenzene in the presence of CuI and Pd(OAc)2 as catalysts. |
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| Keywords: | Indoline-2-thiones Copper 2-Sulfenylindoles Corresponding author |
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