Two ring opened oxetane taxoids containing a C-20 benzoyloxy group from the roots of Taxus wallichiana Zucc. |
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| Authors: | Phu H. Dang Hanh H.T. Nguyen Hien T.T. Truong Truong N.V. Do Hai X. Nguyen Mai T.T. Nguyen Manabu Abe Ryukichi Takagi Nhan T. Nguyen |
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| Affiliation: | 1. Faculty of Chemistry, VNUHCM–University of Science, 227 Nguyen Van Cu, Ho Chi Minh City, Viet Nam;2. Cancer Research Laboratory, Vietnam National University Ho Chi Minh City, 227 Nguyen Van Cu, Ho Chi Minh City, Viet Nam;3. Department of Chemistry, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8526, Japan |
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| Abstract: | Two new taxanes, named wallitaxane G (1) and H (2), were isolated from the roots of Taxus wallichiana (Taxaceae), together with nine known compounds (3?11). Their structures were elucidated on the basis of NMR spectroscopic analysis and the relative configurations of 1 and 2 were determined based on NOESY data. Wallitaxane H (2) showed the most potent α-glucosidase inhibitory activity, with an IC50 value of 16.1 μM. Plausible biosynthetic pathways for the formation of 1 and 2 were proposed based on oxetane ring-opening and benzoyl migration. |
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| Keywords: | Taxaceae Opened-oxetane ring C-20 benzoyloxy α-Glucosidase |
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