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Visible-light-mediated direct perfluoroalkylation and trifluoromethylation of free anilines |
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| Authors: | Chun-Yang He Ji-Wei Gu Xingang Zhang |
| Affiliation: | 1. School of Pharmacy, Zunyi Medical University, No. 6 West Xuefu Road, Zunyi, Guizhou 563003, China;2. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China |
| Abstract: | A mild, operationally simple method for direct perfluoroalkylation and trifluoromethylation of anilines through visible-light-mediated photoredox catalysis from broadly available perfluoroalkyl iodides and free anilines is described. The method provides a facile route for application in drug discovery and development. |
| Keywords: | Perfluoroalkylation Trifluoromethylation Anilines Photoredox catalysis Visible-light |
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