Greener synthesis using hydrogen peroxide in ethyl acetate of alicyclic ring-fused benzimidazoles and anti-tumour benzimidazolequinones |
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Authors: | Martin Sweeney Michael Gurry Lee-Ann J. Keane Fawaz Aldabbagh |
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Affiliation: | School of Chemistry, National University of Ireland Galway, University Road, Galway, Ireland |
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Abstract: | Environmentally-friendly and cost effective hydrogen peroxide in ethyl acetate was used to prepare in high yields pyrrolo[1,2-a]benzimidazoles from commercial o-(pyrrolidin-1-yl)anilines without the requirement for organic-aqueous extraction and chromatography. Six, seven and eight membered ring-fused analogues were similarly obtained in high yields with methanesulfonic acid required for the pyrido[1,2-a]benzimidazole. Anti-tumour benzimidazolequinone derivatives were obtained in high yield via the cyclization of 3,6-dimethoxy-2-(cycloamino)anilines. |
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Keywords: | Annulations Green chemistry Heterocycles Quinones |
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