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Eaton’s reagent-mediated metal-free and efficient synthesis of NH-sulfoximines |
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| Authors: | Jianping Wang Jian Zhang Kun Miao Hongying Yun Hong C Shen Weili Zhao Chungen Liang |
| Institution: | 1. Roche Innovation Center Shanghai, 720 Cailun Road, Building 5, Pudong, Shanghai 201203, China;2. School of Pharmacy, Fudan University, Pudong, Shanghai 201203, China |
| Abstract: | NH-sulfoximines can be prepared efficiently from corresponding sulfoxides in the presence of sodium azide and Eaton’s reagent. This metal-free and efficient methodology is applicable to a wide variety of functionalized sulfoxides to afford NH-sulfoximines in good to excellent yields with shorter reaction time than previously reported methods. |
| Keywords: | Eaton’s reagent Sulfoximine Sodium azide Metal-free synthesis |
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