Copper-catalyzed cross-coupling reactions of non-activated primary,secondary or tertiary alkyl chlorides with phenylmagnesium bromide |
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| Authors: | Chuanzhou Tao Lei Sun Bin Wang Zhou Liu Yadong Zhai Xiulian Zhang Dahua Shi Weiwei Liu |
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| Institution: | 1. School of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, PR China;2. Jiangsu Marine Resources Development Research Institute, Lianyungang 222005, PR China |
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| Abstract: | Efficient copper-catalyzed cross-coupling reactions of non-activated alkyl chlorides, including primary, secondary, and tertiary alkyl chlorides, with phenyl Grignard reagents were achieved. Preparation of phenylmagnesium bromide in 2-methyltetrahydrofuran is critical for the success of the reaction. This protocol expands the synthetic toolbox for the construction of C | |
| Keywords: | Copper-catalyzed Non-activated alkyl chlorides Cross-coupling |
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