A novel anthracene-based fluorescent colorimetric sensor for the simple naked-eye diagnosis of methylmalonic aciduria |
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| Authors: | Hidekazu Miyaji Junko Fujimoto Riho Mabuchi Moeno Okumura Shoichiro Goto Youtaro Honda |
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| Affiliation: | Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan |
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| Abstract: | A novel molecular sensor using anthracene bearing two amidopyridines emits blue fluorescence in the presence of succinic acid and green fluorescence in the presence of malonic acid, and its fluorescence intensity increased upon binding. Using this molecular sensor, we succeeded in detecting the difference of one carbon atom between succinic acid and malonic acid with the naked-eye. Furthermore, when methylmalonic acid was dissolved in urine to provide a model system for methylmalonic aciduria, the fluorescence changed from blue to green, and methylmalonic acid was successfully detected with the naked-eye. |
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| Keywords: | Anthracene Amidopyridine Fluorescent colorimetric sensor Naked-eye diagnosis Methylmalonic aciduria |
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