Two new tetrahydrofuran derivatives from the fungus Mucor spp. SNB-VECD11D isolated from the Chrysomelidae Acalymma bivittula |
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| Authors: | Seindé Touré Isabelle Dusfour Didier Stien Véronique Eparvier |
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| Affiliation: | 1. CNRS, Institut de Chimie des Substances Naturelles (ICSN), Université Paris-Sud, 91198 Gif-sur-Yvette, France;2. Institut Pasteur de la Guyane (IPG), Unité de Contrôle et Adaptation des Vecteurs, 97306 Cayenne, Guyane française, France;3. Sorbonne Universités, UPMC Univ. Paris 06, CNRS, Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), Observatoire Océanologique, 66650 Banyuls-sur-Mer, France |
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| Abstract: | Two new tetrahydrofuran derivatives, mucorinic acids A (1) and B (2) as well as the three known secondary metabolites dehydroabietic acid (3), Δ8-dihydroabietic acid (4) and 8-pimarenic acid (5) were isolated from a solid culture of the fungus Mucor spp. isolated on insect Acalymma bivittula. The structure of these compounds was elucidated by analysis of NMR and MS spectroscopic data. Compounds were tested in antimicrobial and insecticidal assays. Dehydroabietic acid exhibited moderate larvicidal activity on Aedes aegypti larvae with 65% mortality at 10 ppm. Both new compounds 1 and 2 showed interesting antibacterial activity on Staphylococcus aureus and methicillin resistant S. aureus with MIC values in the 8–16 μg/ml. |
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| Keywords: | Fungus Insecticide Antibacterial Corresponding authors. |
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