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Novel synthesis of spirocyclic-3,4-dihydro-2H-benzo[b][1,4]oxazine derivatives |
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| Authors: | A. Tony Kurissery G. Abraham Rajkumar Venkata Satyanarayana Arvapalli Venkatachalam Pitchumani |
| Affiliation: | AMRI Singapore Research Centre, 61 Science Park Road, #05-01 Galen, Science Park II, Singapore 117525, Singapore |
| Abstract: | A two-step procedure involving acid catalyzed ring opening of spirocyclic epoxides with 2-haloanilines and subsequent palladium-catalyzed intramolecular C–O bond formation to provide spirocyclic-3,4-dihydro-2H-benzo[b][1,4]oxazine derivatives is described. |
| Keywords: | Epoxide opening 2-Haloanilines Intramolecular C–O bond Palladium catalysis |
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