A metal-free three components procedure for the synthesis of perfluoroalkyl substituted amidines |
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| Authors: | Han-Jun Ai Chuang-Xu Cai Xinxin Qi Jin-Bao Peng Jun Ying Feng Zheng Xiao-Feng Wu |
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| Institution: | 1. Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou 310018, People’s Republic of China;2. Hangzhou Branch of Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 600 No. 21 Street, Hangzhou, People’s Republic of China;3. Leibniz-Institut für Katalyse e.V. an der Universit Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock, Germany |
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| Abstract: | An interesting multicomponent reaction for the synthesis of perfluoroalkyl substituted amidines has been developed. By using perfluoroalkyl iodides, tert-butyl isocyanides and amines as the substrates, the reactions proceed via somophilic isocyanide insertion. In this catalytic system, no transition-metal catalyst, additional ligands and additives were required. The reaction proceed smoothly and a variety of desired amidines were obtained in moderate to excellent yields. |
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| Keywords: | Amidine Perfluoroalkyl iodides Isocyanides Metal-free Green chemistry |
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