Total synthesis of (+)-crocacin D |
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Authors: | Dias Luiz C de Oliveira Luciana G Vilcachagua Janaína D Nigsch Florian |
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Affiliation: | Instituto de Química, Universidade Estadual de Campinas, UNICAMP, C. P. 6154 Campinas, SP, Brazil. ldias@iqm.unicamp.br |
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Abstract: | [structure: see text] The total synthesis of (+)-crocacin D is described. The convergent asymmetric synthesis relies on the use of a Stille cross-coupling between an (E)-vinyl stannane with an (E)-vinyl iodide to establish the (E,E)-dienamide moiety followed by a mild and efficient copper-catalyzed coupling between (+)-crocacin C and a (Z)-vinyl iodide to establish the challenging (Z)-enamide function. |
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