Stereoselective synthesis of 3,3-diarylacrylonitriles as tubulin polymerization inhibitors |
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| Authors: | Fang Zhenglai Song Yunlong Sarkar Taradas Hamel Ernest Fogler William E Agoston Gregory E Fanwick Phillip E Cushman Mark |
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| Institution: | Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, and Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA. |
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| Abstract: | A series of 3,3-diarylacrylonitriles were synthesized stereoselectively as tubulin polymerization inhibitors for potential use in cancer chemotherapy. This synthetic route features stannylcupration and palladium-catalyzed Stille cross-coupling chemistry, allowing both E and Z isomers of 3,3-diarylacrylonitriles to be prepared in a very short sequence of reactions. |
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