| Synthesis and in Vitro Cytotoxicity of a Novel Conjugate of Polyamide and Phospholipid |
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| 作者姓名： | Yi LIU Yu Lin DENG Rong ZHENG Pei Long ZHANG Hui ZHAI Kc Zhong LIU Chang Jin ZHU |
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| 作者单位： | Yi LIU1，Yu Lin DENG2，Rong ZHENG1，Pei Long ZHANG1，Hui ZHAI，Ke Zhong LIU，Chang Jin ZHU1* 1Department of Applied Chemistry，Beijing Institute of Technology，Beijing 100081 2 School of Life Science and Biotechnology，Beijing Institute of Technology，Beijing 100081 |
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| 基金项目： | 国家自然科学基金;科技部科研项目 |
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| 摘 要： | Small molecules with the ability to target predetermined sequences of DNA would be valuable tools in molecular biology and potentially in human medicine1-3. Synthetic polyamides consisting of N-methylpyrrole (Py), N-methylimidazole (Im) have received spec…
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| 关 键 词： | 合成 聚酰胺 磷脂结合物 细胞毒性 神经母细胞瘤 生物活性 |
| 收稿时间： | 2005-11-06 |
Synthesis and in Vitro Cytotoxicity of a Novel Conjugate of Polyamide and Phospholipid |
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| Yi LIU Yu Lin DENG Rong ZHENG Pei Long ZHANG Hui ZHAI Kc Zhong LIU Chang Jin ZHU.Synthesis and in Vitro Cytotoxicity of a Novel Conjugate of Polyamide and Phospholipid[J].Chinese Chemical Letters,2006,17(5):599-602. |
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| Authors: | Yi LIU Yu Lin DENG Rong ZHENG Pei Long ZHANG Hui ZHAI Ke Zhong LIU Chang Jin ZHU |
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| Abstract: | In order to increase the cell penetration and decrease the cytotoxicity of the synthetic molecule, we designed and synthesized a DNA-binding ligand, which was a conjugate of polyamide and phospholipid. We examined the differences in the effect on cytotoxicity between the conjugate and the native polyamide. As expected that the in vitro cytotoxicity of the conjugate was obviously lower than that of the native polyamide either in HeLa cells or SH-SY5Y neuroblastoma cells. |
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| Keywords: | Polyamide phospholipid conjugate cytotoxicity |
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