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Specifications of a neutron exposure accelerator system for biological effects experiments (NASBEE) in NIRS |
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| Authors: | Mitsuru Suda Takuya Hagihara Noriyoshi Suya Tsuyoshi Hamano Masashi Takada Teruaki Konishi Takeshi Maeda Yasushi Ohmachi Shizuko Kakinuma Kentaro Ariyoshi Yoshiya Shimada Hitoshi Imaseki |
| Affiliation: | aDepartment of Technical Support and Development, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba 263-8555, Japan;bTechnical Support of Research & Development, Neos Tech Co., Ltd., 4-11-13-202, Benten, Chuo-ku, Chiba 206-0045, Japan;cExperimental Radiobiology for Children's Health Research Group, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba 263-8555, Japan |
| Abstract: | We developed a neutron irradiation facility, neutron exposure accelerator system for biological effect experiments (NASBEE) for biological studies in National Institute of Radiological Sciences, Japan. Irradiation field of 2 MeV average neutrons generated by a Be(d–n)B reaction is established. Dose uniformity of 240 mm in diameter irradiation field is producible within ±2.5% with a dose rate of 0.87 Gy/h at sample target distance of 1170 mm. Two irradiation rooms, a specific pathogen-free (SPF) conditioned one and a conventional, are now available. Irradiation protocols for in vitro experiments are now established and demonstrated by obtaining a relative biological effectiveness (RBE) of cell inactivation measured to be 3.54 with 10% survival dose (D10). |
| Keywords: | Accelerator Neutron Biological study SPF Dose measurement |
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