Synthesis and x-ray diffraction study of 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-n-acetic acid dihydroperchlorate

The dihydroperchlorate of 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-N-acetic acid (I) was obtained by the exchange reaction of the dihydrobromide with silver perchlorate. A planar structure of the ligand molecule with methyl and CH₂COOH groups that deviate from the plane of the macroring was established as a result of x-ray diffraction analysis. Numerous hydrogen bonds with the participation of a carboxy group, amino nitrogen atoms, and crystallization water molecules were detected.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1572–1575, November, 1992.