Ethyl 2-nitroacetoacetate as a new synthetic equivalent of ethoxycarbonylnitrile oxide |
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Authors: | V P Kislyi A L Laikhter B I Ugrak V V Semenov |
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Institution: | (1) N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 117913 Moscow, Russian Federation |
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Abstract: | It was shown that ethyl 2-nitroacetoacetate is a synthetic precursor of ethoxycarbonylnitrile oxide as well as of isoxazole- and isoxazoline-3-carboxylic acids and their esters. The elimination of acetic acid from ethyl 2-nitroacetoacetate occurs in a mixture of acetic acid and acetic anhydride in the presence of strong mineral acids,e.g., H2SO4, at room temperature and gives isoxazolines in yields of up to 85–91 %.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 103–105, January, 1994. |
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Keywords: | ethoxycarbonylnitrile oxide isoxazoles isoxazolines |
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