One-pot alpha-glycosylation method using Appel agents in N,N-dimethylformamide |
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| Authors: | Nishida Yoshihiro Shingu Yuko Dohi Hirofumi Kobayashi Kazukiyo |
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| Institution: | Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603, Japan. nishida@mol.nagoya-u.ac.jp |
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| Abstract: | reaction: see text] A concept for the development of practical glycosylation is presented and demonstrated by one-pot alpha-glycosylation applying Appel agents for 2-O-benzyl-1-OH hexoses in DMF. The reaction, in situ giving the equilibrium of glycosyl bromides and more reactive O-glycoside intermediates, accomplishes a near-quantitative alpha-glycosylation removing the water molecules. |
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