Comparison of slow and fast neocortical neuron migration using a new <Emphasis Type="Italic">in vitro</Emphasis>model |
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| Authors: | Anna J Nichols Laurel H Carney Eric C Olson |
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| Institution: | (1) Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA;(2) Department of Biomedical Engineering, University of Rochester, Rochester, NY 14642, USA;(3) Department of Neurobiology & Anatomy, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA |
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| Abstract: | Background Mutations, toxic insults and radiation exposure are known to slow or arrest the migration of cortical neurons, in most cases
by unknown mechanisms. The movement of migrating neurons is saltatory, reflecting the intermittent movement of the nucleus
(nucleokinesis) within the confines of the plasma membrane. Each nucleokinetic movement is analogous to a step. Thus, average
migration speed could be reduced by lowering step frequency and/or step distance. |
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