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A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations |
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| Authors: | Ayaz Muhammad Dietrich Justin Hulme Christopher |
| Institution: | a College of Pharmacy, BIO5 Oro Valley, The University of Arizona, Tucson, AZ, USA b Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ 85721, USA |
| Abstract: | This Letter reveals an innovative and facile procedure to prepare quinoxalines in two synthetic steps. The microwave assisted Petasis reaction is followed by the acid mediated unmasking of an internal amino nucleophile, cyclodehydration and oxidation to give collections of quinoxalines in good to excellent yields. |
| Keywords: | Petasis reaction Multicomponent reaction Quinoxaline Intramolecular cyclization Microwave |
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