Toward an efficient synthesis of taxane analogs by dienyne ring-closing metathesis |
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Authors: | Aldegunde María J Castedo Luis Granja Juan R |
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Affiliation: | Departamento de Química Orgánica, Laboratorios del CSIC, Facultad de Química, Universidad de Santiago, 15782 Santiago de Compostela, Spain. |
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Abstract: | An efficient tandem ring-closing dienyne metathesis of dienynes derived from cyclohex-2-enone affords the [5.3.1] carbon framework characteristic of taxanes in a single-step process. Further stereoselective functionalizations of the resulting [5.3.1] carbon framework lead to an advanced intermediate in a novel synthetic strategy for taxane analogs. |
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