Catalytic enantioselective addition of diethylzinc to trifluoromethyl ketones |
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Authors: | Yearick Kimberly Wolf Christian |
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Affiliation: | Department of Chemistry, Georgetown University, Washington, DC 20057, USA. |
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Abstract: | A procedure for nucleophilic addition of diethylzinc to trifluoromethyl ketones was developed. The TMEDA-catalyzed method converts aromatic substrates to the corresponding 2-aryl-1,1,1-trifluorobutan-2-ols in up to 99% yield, and it is also applicable to less reactive aliphatic ketones if stoichiometric ligand amounts are employed. The first asymmetric variant producing tertiary alcohols with up to 61% ee when TBOX is used as catalyst is described. |
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