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Green and Efficient Synthesis of 3-Pyrazolyl Indoles in Water |
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| Authors: | ZHAO Yanhui YU Haifeng LIAO Peiqiu WANG Wenju |
| Affiliation: | 1. College of Chemistry, Baicheng Normal University, Baicheng 137000, P. R. China;2. Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Faculty of Chemistry, Northeast Normal University, Changchun 130024, P. R. China |
| Abstract: | A green and efficient synthesis of 3-pyrazolyl indoles was developed by the cyclocondensation reaction of β-ethylthio-β-indolyl-α,β-unsaturated ketones with semicarbazide hydrochloride as hydrazine equivalent in the presence of 3 equiv. of PEG-400(1a/PEG mole ratio of 1:3) in reflux water. This procedure did not require toxic hydrazine and product purification, eliminating the use of toxic liquid chemicals. |
| Keywords: | 3-Pyrazolyl indole Green synthesis Semicarbazide hydrochloride Polyethylene glycol Hydrazine equivalent |
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