Coarse-grained lattice model for molecular recognition |
| |
Authors: | Behringer Hans Degenhard Andreas Schmid Friederike |
| |
Affiliation: | Fakult?t für Physik, Universit?t Bielefeld, D-33615 Bielefeld, Germany. |
| |
Abstract: | We present a simple model which allows us to investigate the equilibrium aspects of molecular recognition between rigid biomolecules on a generic level. Using a two-stage approach, which consists of a design and a testing step, the role of cooperativity and of varying bond strength in molecular recognition is investigated. Cooperativity is found to enhance selectivity. In complexes which require a high binding flexibility, a small number of strong bonds seems to be favored compared to a situation with many but weak bonds. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|