Tissue self-affinity and polarized light scattering in the born approximation: a new model for precancer detection |
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Authors: | Hunter Martin Backman Vadim Popescu Gabriel Kalashnikov Maxim Boone Charles W Wax Adam Gopal Venkatesh Badizadegan Kamran Stoner Gary D Feld Michael S |
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Institution: | G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. |
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Abstract: | Light scattered from biological tissues can exhibit an inverse power law spectral component. We develop a model based on the Born approximation and von Karman (self-affine) spatial correlation of submicron tissue refractive index to account for this. The model is applied to light scattering spectra obtained from excised esophagi of normal and carcinogen-treated rats. Power law exponents used to fit dysplastic tissue site spectra are significantly smaller than those from normal sites, indicating that changes in tissue self-affinity can serve as a potential biomarker for precancer. |
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