Development of an improved method for trace analysis of chloramphenicol using molecularly imprinted polymers |
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Authors: | Boyd Brian Björk Henrik Billing Johan Shimelis Olga Axelsson Sara Leonora Maria Yilmaz Ecevit |
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Affiliation: | MIP Technologies AB, Box 737, Lund 22007, Sweden. brian.boyd@miptechnologies.com |
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Abstract: | A confirmatory method is described for the determination of the illegal antibiotic chloramphenicol using a specifically developed molecularly imprinted polymer (MIP) as the sample clean-up technique. The newly developed MIP was produced using an analogue to chloramphenicol as the template molecule. Using an analogue of the analyte as the template avoids a major traditional drawback associated with MIPs of residual template leeching or bleeding. The MIP described was used as a solid-phase extraction phase for the extraction of chloramphenicol from various sample matrices including honey, urine, milk and plasma. A full analytical method with quantification by LC-MS/MS is described. The method was fully validated according to the European Union (EU) criteria for the analysis of veterinary drug residues. |
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