Preparation,characterization and cytotoxic activity of new compounds trans-[PtCl2NH3(3-(hydroxymethyl)-pyridine)] and trans-[PtCl2NH3(4-(hydroxymethyl)-pyridine)] |
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| Affiliation: | 1. Department of Applied Chemistry, Cochin University of Science and Technology, Kochi 682 022, Kerala, India;2. Department of Chemistry, Faculty of Science, Eastern University, Sri Lanka, Chenkalady, Sri Lanka;1. Bioinformatics Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran;2. Department of Physics, Faculty of Science, Bilkent University, Ankara, Turkey;3. Department of Chemistry, Faculty of Science, Tarbiat Modares University, Tehran, Iran;1. Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia;2. Department of Physics, Fatima Mata National College, Kollam, Kerala, India;3. University of Novi Sad, Faculty of Sciences, Department of Physics, Trg D. Obradovića 4, 21000 Novi Sad, Serbia;4. University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Trg D. Obradovića 3, 21000 Novi Sad, Serbia;5. Department of Chemistry, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium |
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| Abstract: | We report the synthesis, characterization and cytotoxic assays of new trans-platinum compounds, trans-[PtCl2NH3(3-(hydroxymethyl)-pyridine)] and trans-[PtCl2NH3(4-(hydroxymethyl)-pyridine)]. In the present work, we found that the replacement of the ammine ligand in “classical” transplatinum with the two new ligands does not increase the cytotoxic activity, maybe because these complexes do not produce a stability of the intrastrand cross-links in DNA. |
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