Heterocyclic pentafluorophenyl sulfonate esters as shelf stable alternatives to sulfonyl chlorides |
| |
| Authors: | Jan Bornholdt Jakob Felding |
| |
| Affiliation: | a Department of Medicinal Chemistry, University of Copenhagen, Faculty of Pharmaceutical Sciences, Universitetsparken 2, 2100 Copenhagen, Denmark
b Leo-pharma A/S, Industriparken 55, 2750 Ballerup, Denmark |
| |
| Abstract: | Heterocyclic pentafluorophenyl sulfonate esters are shelf stable alternatives to the often less stable sulfonyl chlorides. They are easily prepared from thiols and react readily with primary and secondary amines to produce sulfonamides in high yields. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
