SmI2-mediated dialdehyde ‘radical then aldol’ cyclization cascades: a feasibility study |
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| Authors: | Matthew D. Helm |
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| Affiliation: | School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK |
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| Abstract: | Dialdehydes undergo ‘radical then aldol’ cyclization cascades upon treatment with SmI2, generating four contiguous stereocenters with high diastereocontrol. The scope of the process has been explored and the cascade has been extended to also include lactone reduction. |
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| Keywords: | Samarium Radical Cyclization Cascade |
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