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Efficient di-bromination of 5-pyrazolones and 5-hydroxypyrazoles by N-bromobenzamide |
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| Authors: | Yu-Ying Huang Kaung-Min Cheng Kuan-Chin Sung Jiann-Jyh Huang Fung Fuh Wong |
| Affiliation: | a Graduate Institute of Pharmaceutical Chemistry, China Medical University, No. 91, Hsueh-Shih Rd., Taichung 40402, Taiwan, ROC b Department of Surgery, Attending Physician Neurosurgery, No. 201, Taikang Village, Liouying Township 709, Taiwan ROC c Development Center for Biotechnology, No. 101, Lane 169, Kangning St., Xizhi City, Taipei County 221, Taiwan ROC d Sustainable Environment Research Center, National Cheng Kung University, No. 500, Sec. 3, An-ming Rd., Tainan City 709, Taiwan ROC |
| Abstract: | An efficient and convenient method for the bromination of pyrazolones and 5-hydroxypyrazoles was developed by using N-bromobenzamide in THF at room temperature. This new method provided di-bromimated pyrazolones in excellent yields (≥90%). |
| Keywords: | Bromination N-Bromobenzamide Pyrazolones 5-Hydroxypyrazoles |
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