DBU-Catalyzed, facile and efficient method for synthesis of spirocyclic 2-oxindole derivatives with incorporated 6-amino-4H-pyridazines and fused derivatives via [3+3] atom combination |
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| Authors: | Ismail A Abdelhamid Mona H Mohamed Said AS Ghozlan |
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| Institution: | a Chemistry Department, Faculty of Science, Cairo university Giza, Egypt
b Institut für Organische Chemie der Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany |
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| Abstract: | 3-Cyanomethylidene oxindole derivatives were prepared in excellent yields utilizing DBU-promoted Knoevenagel condensation of isatin derivatives with active methylene reagents. The isolated products were then reacted with azaenamines via a DBU-promoted Michael addition to yield spirocyclic 2-oxindole derivatives with incorporated 6-amino-4H-pyridazines and their fused derivatives. |
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| Keywords: | 3-Cyanomethylidene oxindole DBU Azaenamines Michael addition Spiropyridazines |
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