Total synthesis of 8-oxypseudopalmatine and 8-oxypseudoberberine via ring-closing metathesis |
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| Authors: | Hue Thi My Van Daulat Bikram Khadka Won-Jea Cho |
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| Affiliation: | a College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Yong-Bong dong, Buk-gu, Gwangju 500-757, Republic of Korea
b Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryong-dong, Buk-gu, Gwangju 500-712, Republic of Korea |
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| Abstract: | Concise synthesis of 8-oxypseudopalmatine and 8-oxypseudoberberine has been achieved using ruthenium-catalyzed ring-closing metathesis (RCM) as the key step, in which the RCM substrates, 3-arylisoquinolinones, were prepared by lithiated cycloaddition reaction with o-toluamides and benzonitriles. |
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| Keywords: | 8-Oxypseudopalmatine 8-Oxypseudoberberine 3-Arylisoquinolinones Ring-closing metathesis |
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