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The first synthesis of 2-amino-1,4-dihydroquinolines |
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| Authors: | Guillaume Viault Thierry Roisnel René Grée |
| Institution: | a Université de Rennes 1, Laboratoire CPM, CNRS UMR 6510, Avenue du Général Leclerc, 35042 Rennes Cedex, France b Université de Rennes 1, Sciences Chimiques de Rennes, CNRS UMR 6226, Campus de Beaulieu, 35042 Rennes-Cedex, France c Indian Institute of Chemical Technology, 500607 Hyderabad, India |
| Abstract: | A versatile strategy is described for the synthesis of new 2-amino-1,4-dihydroquinolines. It involved a Knoevenagel condensation of N-protected-2-amino-5-bromobenzaldehyde with ethylcyanoacetate, followed by a cyclization and protection of the NH group to afford the key intermediates 7 or 19. Then various 1,4 addition reactions have been performed to introduce substituents on the upper part of the 2-amino-1,4-dihydroquinolines. |
| Keywords: | 1 4-Dihydroquinolines HA 14-1 Benzopyran Anti-cancer Bcl-2 |
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