Enantioselective synthesis of functionalized 3,4-dihydropyran derivatives organocatalyzed by a novel fluorinated-diphenylprolinolether |
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| Authors: | Chuanming Yu Fei Zheng Haiwei Ye Weihui Zhong |
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| Affiliation: | Key Laboratory of Pharmaceutical Engineering of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, PR China |
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| Abstract: | A novel fluorinated diarylprolinol silyl ether catalyst have been designed and it successfully applicated in the first asymmetric Michael addition-cyclization reaction between 1,3-dicarbonyl compounds with α,β-unsaturated aldehydes at room temperature. The products were isolated in good yields with high diastereoselectivities and enantioselectivities. |
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| Keywords: | Pyrans Fluorinated diphenylprolinolether Organocatalyst Domino reactions |
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