Highly enantioselective desymmetrization of meso- and prochiral cyclic ketones via organocatalytic Michael reaction |
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| Authors: | Jia-Rong Chen |
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| Institution: | Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China |
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| Abstract: | An efficient and novel organocatalyst has been developed for the asymmetric desymmetrization of meso- and prochiral ketones by direct Michael addition to nitroolefins. This strategy can afford the desymmetrization products with excellent diastereo- (up to >99:1) and enantioselectivity (up to 96%) in great yields (up to 95%). |
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