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Cembrane diterpenoids from the Taiwanese soft coral Sinularia flexibilis |
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| Authors: | Yun-Sheng Lin Chung-Hsiung Chen Yu-Chen Chen Ya-Ching Shen |
| Affiliation: | a Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, ROC b School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Rd. Sec. 1, Taipei 100, Taiwan, ROC c National Research Institute of Chinese Medicine, Taipei 112, Taiwan, ROC |
| Abstract: | Chemical investigation of the soft coral Sinularia flexibilis (Quoy and Gaimard), collected from the southern coast of Taiwan, led to the isolation of 10 new cembrenoid diterpenoids, the flexilarins A-J (1-10), along with 17 known compounds (11-27). The structures of these compounds were elucidated by spectroscopic techniques (NMR, MS, UV, IR). The structure of compound 1 was confirmed by X-ray crystallographic analysis. Compound 4 exhibited potent cytotoxicity against Hep2 tumor cells. |
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