交联聚苯乙烯微球的表面化学改性及吡啶基卟啉的固载化

以无致癌毒性的1,4-二氯甲氧基丁烷为氯甲基化试剂,先将交联聚苯乙烯(CPS)微球氯甲基化,制得氯甲基化微球CMCPS。 然后使微球CMCPS与4-吡啶甲醛进行季铵化反应,将4-吡啶甲醛键合到CPS微球表面,制得键合吡啶甲醛(PyAL)的改性微球PyAL-CPS。 考察了主要反应条件对季铵化反应的影响,最终确定季铵化反应的优化条件:溶剂CCl4，反应温度60 ℃，最后使改性微球PyAL-CPS、4-吡啶甲醛及吡咯在固-液界面上进行Adler反应,形成固载吡啶基卟啉(PyP)的微球PyP-CPS。 用IR和UV-Vis以及Zn2+配合物生成法表征了微球PyP-CPS的形成及负载量。

Surface Chemical Modification of Crosslinked Polystyrene Microspheres and Immobilization of Pyridyl Porphyrins

Crosslinked polystyrene microspheres(CPS) were first chloromethylated with non carcinogenic 1,4-bis(chloromethoxy)butane(BCMB) to form chloromethylated microspheres(CMCPS). Then quaternization reaction between CMCPS microspheres and 4-pyridylaldehyde was carried out to modify the CPS microspheres with 4-pyridylaldehyde(PyAL-CPS). The effects of main factors on the quaternization reaction were examined, and the synthetic conditions were optimized. The suitable temperature and appropriate solvent are 60 ℃ and CCl4, respectively. Finally, Alder reaction at the interface of solid/solution between 4-pyridylaldehyde on the surface of modified microspheres and pyrrole was performed to form the functional microspheres(PyP-CPS), on which the formation of pyridyl porphyrin(PyP) could be achieved. The PyP-CPS formation were characterized by using IR and UV-Vis while and the loading of PyP was demonstrated by forming Zn-PyP complex.