放射性125I粒子组织间植入对人前列腺癌裸鼠皮下移植瘤（DU145）抑制作用的实验研究

目的：观察125I例子组织间植入对人前列腺癌裸鼠皮下移植瘤（DU145）的抑制作用。方法：:雄性裸鼠50只，建立DU145前列腺癌细胞裸鼠移植瘤动物模型，分成5组（每组10只），5只分别植入125I粒子，给予不同时间，不同剂量的照射、5只植入假源。每天观察肿瘤横径，垂直径，记录移植瘤体积变化。处死动物后，对取下的瘤体做免疫组化及病理学分析。结果：各粒子植入植入组与假源组比较，肿瘤体积有不同程度的改变（植入组＜对照组）,证明125I粒子植入对前列腺癌细胞DU145移植瘤有抑制作用，但144h组、216h组之间瘤重抑制率相比无统计学意义(P>0.05)。各粒子植入组Bax、Caspase-3、Caspase-9蛋白表达的相对含量较假源组增多（P<0.05）；组织病理学研究显示不同剂量，不同照射时间，肿瘤细胞凋亡程度不同。结论:125I粒子持续低剂量率照射可以抑制前列腺癌裸鼠皮下移植瘤（DU145）的生长，照射时间，照射剂量不同，抑制的效果不同。

Experiment of Implanting ~(125)I Seed Radiation to Treat Nude Mouse with Prostatic Cancer(DU145)

To observe the effect of 125I particles implanting on the growth of Du-145(a common Prostate Cancer cell lines),fifty male nude mice were divided into five groups(each group 10),and DU145 cells were injected into the mice subcutaneously to construct the model.Five of the ten mice in each group were implanted in the tumors with 125I particles,and the other five were implanted with no-radiation particles as controls.Each group were give differential period of radical time and dose.Measuring the diameter of th...