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Chemoenzymatic synthesis of highly enantiomerically enriched secondary alcohols with a thiazolic core |
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| Authors: | Laura Pop Pierrik Lassalas László Csaba Bencze Monica Ioana To?a Botond Nagy Florin Dan Irimie Christophe Hoarau |
| Institution: | 1. Department of Biochemistry and Biochemical Engineering, University Babe?-Bolyai Cluj-Napoca, Ro-400028 Cluj-Napoca, Arany János 11, Romania;2. Institut de Chimie Organique Fine (IRCOF) associé au CNRS (UMR 6014), INSA et Université de Rouen, BP08, 76131 Mont Saint Aignan, France |
| Abstract: | Stereoselective preparative enzymatic acylation and hydrolysis/methanolysis of various C-substituted rac-thiazol-2-yl-methanols were achieved for the preparation of enantiopure or enantiomerically enriched, naturally occurring 2-hydroxymethylthiazoles. The absolute configurations of the resulting secondary alcohols were determined by a detailed 1H NMR study of Mosher’s derivatives. |
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