A novel lipase enzyme panel exhibiting superior activity and selectivity over lipase B from Candida antarctica for the kinetic resolution of secondary alcohols |
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| Authors: | Maeve O’Neill Denis Beecher David Mangan Andrew S Rowan Agnieszka Monte Stefan Sroka Jan Modregger Bhupinder Hundle Thomas S Moody |
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| Institution: | 1. Almac, Biocatalysis Group, David Keir Building, Stranmillis Road, Belfast, Northern Ireland, BT9 5AG, UK;2. EUCODIS Bioscience GmbH, Campus Vienna Biocenter II, Viehmarktgasse 2 a/2. OG, 1030 Vienna, Austria |
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| Abstract: | A novel, commercially available lipase enzyme panel performing kinetic bioresolutions of a number of secondary alcohols is reported. The secondary alcohols that have been chosen are known from the literature to be particularly challenging substrates to resolve. Following initial screening, four co-solvents were investigated for each lead enzyme in an effort to assess their tolerance to common organic solvents. The superiority of these novel enzymes over lipase B from Candida antarctica (CALB) has been demonstrated. |
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